DNA Cytosine Demethylation: Are We Getting Close?
نویسندگان
چکیده
Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.
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ورودعنوان ژورنال:
- Cell
دوره 135 شماره
صفحات -
تاریخ انتشار 2008